Downtown St. Louis Vacations from $428
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Your Downtown St. Louis Vacation
A sought-after riverside neighborhood, Downtown St. Louis tempts visitors with its festivals, bars and pubs and dining. Lock in a vacation package to Downtown St. Louis and look forward to experiencing all the best bits for yourself. Some top nearby attractions to check out during your trip to Downtown St. Louis include Busch Stadium, Gateway Arch and Dome at America’s Center. Expedia will help you turn your ideal Downtown St. Louis vacation into reality, no matter your travel plans or budget.
The Latest Downtown St. Louis Vacation Packages
Price found within the past 48 hours. Click for updated prices.
The Cheshire
Price was $1,136, price is now $791 per person
$791
per person
Dec 25 - Jan 1
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.8/10 Excellent! (1,010 reviews)
The Cheshire Inn is a landmark in St Louis, so we wish it all the best. It has been ten years since we last stayed there and, in that time, the Cheshire has deteriorated. Our room was clean and comfortable, but the rest of the establishment was dirty--elevator, breakfast area and lobby. The breakfast was just okay and the coffee which is SO important was way too strong. It was near the strength of expresso. The coffee is Starbucks which leans to the more robust strength, but their coffee was beyond that. I prefer cream in my coffee but will drink it black. The only "cream" available was sweetened (first ingredient listed was syrup), The morning coffee in bed is a treat I look forward to when overnight at a hotel. That didn't happen at the Cheshire.
Reviewed on Nov 9, 2026
Where to stay in Downtown St. Louis
Find the best Downtown St. Louis areas and neighborhoods for the activities you enjoy most. Learn more about Downtown St. Louis
Clayton
1 out of top 10 points of interest in this area
Visitors often come to Clayton for its abundant dining options, but many stay to explore sights like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. Getting around the area on the metro is easy if you catch a ride at Clayton Station.
Downtown St. Louis Hotel Deals
Drury Plaza Hotel St. Louis at the Arch
2 South 4th Street St. Louis MO
Fully refundableReserve now, pay when you stay
$144 nightly
The price is $168 total per night from Nov 15 to Nov 16
$168 total
Nov 15 - Nov 16
Total with taxes and fees
Hyatt Regency St. Louis at The Arch
315 Chestnut St St. Louis MO
Fully refundableReserve now, pay when you stay
$113 nightly
The price is $133 total per night from Nov 27 to Nov 28
$133 total
Nov 27 - Nov 28
Total with taxes and fees
8.6/10 Excellent! (4,405 reviews)
"Staff was friendly the food was good. I had a pleasant stay."
Reviewed on Nov 10, 2026
Live by Loews - St.Louis
799 Clark ave St. Louis MO
Fully refundableReserve now, pay when you stay
$139 nightly
The price is $165 total per night from Nov 15 to Nov 16
$165 total
Nov 15 - Nov 16
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Stay near popular Downtown St. Louis attractions
Things to do
St. Louis Ghost Tour: Sinister Sins & Shadows
$24
per adult
100% of travellers recommend
Haunted Lemp Brewery Bottle Works Paranormal Tour
$25
per adult
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- Samuel Cupples House
- Wainwright Building
- Washington Avenue Historic District
- Dome at America’s Center
- Cathedral Basilica of St. Louis
- America's Center Convention Complex
- Gateway Arch National Park
- Eugene Field House & St. Louis Toy Museum
- Kiener Plaza
- Visit St. Louis
- St. Louis Cathedral
- Magic House - St. Louis Children's Museum
- Central Public Library
- Chaifetz Arena
- Fox Theater
- St. Louis Science Center
- St. Louis Union Station Mini Golf
- Gateway Arch Visitor Center
- Jewel Box
- St. Louis Vacations
- City Museum
- Meeting of the Waters Fountain
- St. Louis City Hall
- Christ Church Cathedral
- The MOTO Museum
- Campbell House Museum
- St. Mary of Victories Catholic Church
- Grant's Farm
- Bruno David Gallery
- St. Alphonsus Liguori Catholic Church
- St. Louis Aquarium at Union Station
- The Muny Theater
- National Blues Museum
- Where to stay in St. Louis
- Citygarden Sculpture Park
- Soulard Farmer's Market
- Missouri Botanical Gardens and Arboretum
- Museum at the Gateway Arch
- Enterprise Center
- St. Louis Art Museum
- St. Louis Zoo
- Old Post Office
- Citygarden
- Eads Bridge
- Gateway Arch
- Busch Stadium
- Old Courthouse
- Horseshoe St. Louis Casino
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.